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Welcome to Moddose,
We are all about staying younger for longer. And if that means taking supplements every day, so be it.
Everyone knows what exercise is, it’s something we all should do, but many of us don’t. But being lazy is not always an excuse.
Many older adults have physical limitations. In the study below, researchers looked for treatments for physical function limitations in older adults by combing Resveratrol and Exercise.
What is Resveratrol?
Resveratrol is a natural antioxidant found in red grape skin, Japanese knotweed, peanuts, blueberries, etc. The Japanese knotweed contains the highest natural Resveratrol content with red grape skin in second. But Resveratrol has been concentrated and is available to buy in pill form, HERE.
Adequate exercise is one of the most effective lifestyle interventions to improve aging, but many people, especially older adults, can find it difficult to exercise.
In a study published this month, researchers tested the effects of resveratrol as an adjuvant therapy to exercise for older adults with physical limitations.
The word “adjuvant” has roots in Latin that mean “helping toward.” Adjuvant therapies are add-ons that may improve the effectiveness of other interventions.
Resveratrol activates mitochondria through a protein called PGC-1α, the master regulator of mitochondrial biogenesis.
Therefore, resveratrol may boost the benefits of exercise by enhancing mitochondrial adaptation in skeletal muscle.
The purpose of this randomized controlled pilot study was to determine the safety and feasibility of chronic exercise combined with resveratrol supplementation.
The investigators split a group of 60 adults (average age, 71 years) who had physical limitations into three smaller groups.
All three groups completed supervised walking and whole-body resistance training twice weekly for 12 weeks.
One group took 500 milligrams of resveratrol daily, another took 1,000 milligrams of resveratrol daily,
and one group took a placebo.
The participants completed a battery of physical function tests and gave blood so the researchers could measure markers of cardiovascular risk.
On average, participants completed 82 percent of their exercise sessions and took 85 percent of their resveratrol doses, indicating that the intervention was acceptable for most participants.
The rate of adverse events was similar between groups, with an average of nine events, indicating that the intervention was safe.
Most adverse events were mild and included gastrointestinal or musculoskeletal issues and dizziness.
Pilot studies are not designed to evaluate the effect of the study intervention on health; however, the authors reported some promising early results.
Participants in the 1,000-milligram group exhibited a clinically significant increase of 449 meters in their 6-minute walk test and increased levels of citrate synthase, a common marker of mitochondrial volume.
The authors are planning a large-scale clinical trial to build on these preliminary results.
Link to the full study.
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